Association of BRAF V600E immunoexpression with clinicopathological variant groups in papillary thyroid carcinoma

The detection of BRAF V600E immunoexpression in papillary thyroid carcinoma (PTC) is extremely important because its association with poor prognosis. Is prognosis really associated all histological variants carcinoma? To contribute to this elucidation, using the mutation-specific antibody, present study was performed determine between and clinicopathological variant groups PTC. Tumour tissue samples collected from 95 patients cancer tumour size <3.5 cm diameter were processed by routine microscopic technique Ventana Benchmark XT automated stainer. group aggressive directly proportional lymph node distal metastasis (p=0.005) contrast favourable group. Finally, nodal (poor prognosis) PTC can be better predicted when combining immunostaining conventional histopathological technique, conversely, these results could not achieved These findings suggest that a potential candidate for